MER/SKY (phospho Tyr749/681) Antibody

Product Specifications

Background

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) .

NCBI Gene ID

10461;7301

Swiss Prot

Q12866; Q06418

Accession Number

NP_006334.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MER/SKY (phospho Tyr749/681) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 749/681 (K-I-Y (p) -S-G) derived from Human MER/SKY .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

97 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MER/SKY only when phosphorylated at tyrosine 749/681.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

MERTK, TYRO3

NCBI Official Name

MER proto-oncogene, tyrosine kinase, TYRO3 protein tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Graham D.K., Cell Growth Differ. 5:647-657 (1994) .

Background Reference 02

Gal A., Nat. Genet. 26:270-271 (2000) .

Background Reference 03

Hillier L.W., Nature 434:724-731 (2005) .

Other Product Names

C-mer, MERK, MERTK

Tested Applications

WB, IHC

Protein ID

66932918

Physical Properties

Liquid

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