MAP3K8 (phospho Ser400) Antibody

Product Specifications

Background

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1) .

NCBI Gene ID

1326

Swiss Prot

P41279

Accession Number

NP_001231063.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MAP3K8 (phospho Ser400) antibody was raised against a peptide sequence around phosphorylation site of Serine 400 (C-Q-S (p) -L-D) derived from HumanMAP3K8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

52 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400.

Symbol

MAP3K8

NCBI Official Name

Mitogen-activated protein kinase kinase kinase 8

NCBI Organism

Homo sapiens

Background Reference 01

Miyoshi J., Mol. Cell. Biol. 11:4088-4096 (1991) .

Background Reference 02

Aoki M., J. Biol. Chem. 268:22723-22732 (1993) .

Background Reference 03

Chan A.M., Oncogene 8:1329-1333 (1993) .

Other Product Names

C-COT; , M3K8, MAP3K8, TPL2

Tested Applications

IHC

Protein ID

22035598

Physical Properties

Liquid

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