LATS1/2 (phospho Thr1079/1041) Antibody

Product Specifications

Background

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.

NCBI Gene ID

9113;26524

Swiss Prot

O95835; Q9NRM7

Accession Number

NP_004681.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

LATS1/2 (phospho Thr1079/1041) antibody was raised against a peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T (p) -F-R) derived from Human LATS1/2 .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20&#730, C for up to one year.

Calculated Molecular Weight

126 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of LATS1/2 only when phosphorylated at threonine 1079/1041.

Symbol

LATS1, LATS2

NCBI Official Name

Large tumor suppressor kinase 1, large tumor suppressor kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Tao W., Nat. Genet. 21:177-181 (1999) .

Background Reference 02

Nishiyama Y., FEBS Lett. 459:159-165 (1999) .

Background Reference 03

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

Other Product Names

WARTS, Large tumor suppressor 1, EC 2.7.11.1

Tested Applications

IHC

Protein ID

4758666

Physical Properties

Liquid

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