IRAK1 (phospho Ser376) Antibody

Product Specifications

Background

IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.

NCBI Gene ID

3654

Swiss Prot

P51617

Accession Number

NP_001560.2

Host

Rabbit

Reactivity

Human

Immunogen

IRAK1 (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Q-S-S (p) -M-V) derived from Human IRAK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific , Inflammasomes

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

76 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of IRAK1 only when phosphorylated at serine 376.

Symbol

IRAK1

NCBI Official Name

Interleukin-1 receptor-associated kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Cao Z., Science 271:1128-1131 (1996) .

Background Reference 02

Reichwald K., Mamm. Genome 11:182-190 (2000) .

Background Reference 03

Jensen L.E., J. Biol. Chem. 276:29037-29044 (2001) .

Other Product Names

IL1RAK, IRAK, mPLK

Tested Applications

IHC

Protein ID

8928535

Physical Properties

Liquid

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