ILK (phospho Ser246) Antibody

Product Specifications

Background

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

3611

Swiss Prot

Q13418

Accession Number

NP_001014794.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

ILK (phospho Ser246) antibody was raised against a peptide sequence around phosphorylation site of Serine 246 (I-F-S (p) -H-P) derived from Human ILK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

51 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of ILK only when phosphorylated at serine 246.

Symbol

ILK

NCBI Official Name

Integrin-linked kinase

NCBI Organism

Homo sapiens

Background Reference 01

Hannigan G.E., Nature 379:91-96 (1996) .

Background Reference 02

Janji B., Oncogene 19:3069-3077 (2000) .

Background Reference 03

Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

Other Product Names

ILK1, p59ILK, kinase ILK

Tested Applications

IHC

Protein ID

4758606

Physical Properties

Liquid

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