IKK-γ (phospho Ser376) Antibody

Product Specifications

Background

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.

NCBI Gene ID

8517

Swiss Prot

Q9Y6K9

Accession Number

NP_001093327.1

Host

Rabbit

Reactivity

Human

Immunogen

IKK-γ (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Y-L-S (p) -S-P) derived from Human IKK-γ.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

48 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.

Symbol

IKBKG

NCBI Official Name

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

NCBI Organism

Homo sapiens

Background Reference 01

Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047 (1999) .

Background Reference 02

Jin D.-Y., J. Biomed. Sci. 6:115-120 (1999) .

Background Reference 03

Rothwarf D.M., Nature 395:297-300 (1998) .

Other Product Names

FIP3, IKBKG, IKKAP1, IKKG, NF-kappaB

Tested Applications

IHC

Protein ID

3641279

Physical Properties

Liquid

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