BLK (phospho Tyr501) Antibody

Product Specifications

Background

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor.

NCBI Gene ID

640

Swiss Prot

P51451

Accession Number

NP_001706.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

BLK (phospho Tyr501) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y (p) -E-L) derived from Human BLK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

57 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501.

Symbol

BLK

NCBI Official Name

B lymphoid tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Islam K.B., J. Immunol. 154:1265-1272 (1995) .

Background Reference 02

Drebin J.A., Oncogene 10:477-486 (1995) .

Background Reference 03

Greenman C., Nature 446:153-158 (2007) .

Other Product Names

P55-BLK, EC 2.7.10.2, kinase Blk, B lymphocyte kinase, Tyrosine-protein kinase BLK

Tested Applications

IHC

Protein ID

33469982

Physical Properties

Liquid

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