ALK (phospho Tyr1096) Antibody

Product Specifications

Background

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs) . The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain.

NCBI Gene ID

238

Swiss Prot

Q9UM73

Accession Number

NP_004295.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

ALK (phospho Tyr1096) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y (p) -C-F) derived from Human ALK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

176 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1096.

Symbol

Alk

NCBI Official Name

Anaplastic lymphoma receptor tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Morris S.W., Oncogene 14:2175-2188 (1997) .

Background Reference 02

Morris S.W., Oncogene 15:2883-2883 (1997) .

Background Reference 03

Iwahara T., Oncogene 14:439-449 (1997) .

Other Product Names

ALK tyrosine kinase receptor, anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), CD246; EC 2.7.10.1, kinase ALK

Tested Applications

IHC

Protein ID

110347475

Physical Properties

Liquid

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