Tau (phospho Ser519/202) Antibody

Product Specifications

Background

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

NCBI Gene ID

4137

Swiss Prot

P10636

Accession Number

NP_058519.3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Tau (phospho Ser519/202) antibody was raised against a peptide sequence around phosphorylation site of Serine 519/202 (P-G-S (p) -P-G) derived from Human Tau.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

85 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Tau only when phosphorylated at serine 519/202.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

TAU

NCBI Official Name

Microtubule-associated protein tau

NCBI Organism

Homo sapiens

Background Reference 01

Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055 (1988) .

Background Reference 02

Goedert M., EMBO J. 8:393-399 (1989) .

Background Reference 03

Lee G., Neuron 2:1615-1624 (1989) .

Other Product Names

MAPT, MTBT1, PHF-tau

Tested Applications

Protein ID

294862261

Physical Properties

Liquid

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