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Retinoblastoma (phospho Ser608) Antibody

Product Specifications

Background

Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.

NCBI Gene ID

5925

Swiss Prot

P06400

Accession Number

NP_000312.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Retinoblastoma (phospho Ser608) antibody was raised against a peptide sequence around phosphorylation site of Serine 608 (Y-L-S (p) -P-V) derived from Human Retinoblastoma.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

110 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Retinoblastoma only when phosphorylated at serine 608.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

RB1

NCBI Official Name

Retinoblastoma 1

NCBI Organism

Homo sapiens

Background Reference 01

Lee W.-H., Nature 329:642-645 (1987) .

Background Reference 02

Lee W.-H., Science 235:1394-1399 (1987) .

Background Reference 03

Friend S.H., Proc. Natl. Acad. Sci. U.S.A. 84:9059-9063 (1987) .

Other Product Names

P105-RB, PP105, PP110, RB1

Tested Applications

WB, IHC

Protein ID

108773787

Physical Properties

Liquid

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