P53 (phospho Thr387) Antibody

Product Specifications

Background

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

NCBI Gene ID

7157

Swiss Prot

P04637

Accession Number

NP_000537.3

Host

Rabbit

Reactivity

Human

Immunogen

P53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p) -E-G) derived from Human p53.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

43 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.

Symbol

TP53

NCBI Official Name

Tumor protein p53

NCBI Organism

Homo sapiens

Background Reference 01

Zakut-Houri R., EMBO J. 4:1251-1255 (1985) .

Background Reference 02

Lamb P., Mol. Cell. Biol. 6:1379-1385 (1986) .

Background Reference 03

Harlow E., Mol. Cell. Biol. 5:1601-1610 (1985) .

Other Product Names

TP53, tumor protein p53, Tumor suppressor p53

Tested Applications

IHC

Protein ID

120407068

Physical Properties

Liquid

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