IGF1R (phospho Tyr1346) Antibody

Product Specifications

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

NCBI Gene ID

3480

Swiss Prot

P08069

Accession Number

NP_000866.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p) -A-H) derived from Human IGF1R .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

154 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.

Symbol

IGF1R

NCBI Official Name

Insulin-like growth factor 1 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Ullrich A., EMBO J. 5:2503-2512 (1986) .

Background Reference 02

Abbot A.M., J. Biol. Chem. 267:10759-10763 (1992) .

Background Reference 03

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Other Product Names

CD221, kinase IGF1R, IGF1R

Tested Applications

IHC

Protein ID

4557665

Physical Properties

Liquid

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