IGF2R (phospho Ser2409) Antibody

Product Specifications

Background

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

NCBI Gene ID

3482

Swiss Prot

P11717

Accession Number

NP_000867.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

IGF2R (phospho Ser2409) antibody was raised against a peptide sequence around phosphorylation site of Serine 2409 (Q-D-S (p) -E-D) derived from Human IGF2R.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

300 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of IGF2R only when phosphorylated at serine 2409.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

IGF2R

NCBI Official Name

Insulin-like growth factor 2 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Morgan D.O., Nature 329:301-307 (1987) .

Background Reference 02

Oshima A., J. Biol. Chem. 263:2553-2562 (1988) .

Background Reference 03

Killian J.K., Mamm. Genome 10:74-77 (1999)

Other Product Names

CI-MPR, CI-MPR, MPR300, MPRI

Tested Applications

WB, IHC

Protein ID

317373416

Physical Properties

Liquid

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