TGF beta Receptor II (phospho Ser225/250) Antibody

Product Specifications

Background

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.

NCBI Gene ID

7048

Swiss Prot

P37173

Accession Number

NP_003233.4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p) -D-I) derived from Human TGF beta Receptor II.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

64 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250.

Symbol

TGFBR2

NCBI Official Name

Transforming growth factor, beta receptor II (70/80kDa)

NCBI Organism

Homo sapiens

Background Reference 01

RC Tripathi, Invest. Ophthalmol. Vis. Sci., Jan 1993; 34: 260.

Background Reference 02

N Chegini, Endocrinology, Jul 1994; 135: 439.

Background Reference 03

GW Mulheron, Endocrinology, Dec 1992; 131: 2609

Other Product Names

TGF-betaR2, TGFR2, kinase TGF-beta-R2

Tested Applications

IHC

Protein ID

67782324

Physical Properties

Liquid

Curated Selection

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