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Bax (phospho Thr167) Antibody

Product Specifications

Background

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

NCBI Gene ID

581

Swiss Prot

Q07812

Accession Number

NP_620116.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Bax (phospho Thr167) antibody was raised against a peptide sequence around phosphorylation site of threonine167 (P-G-T (p) -P-T) derived from Human Bax.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

21 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Bax only when phosphorylated at threonine 167.

Symbol

BAX

NCBI Official Name

BCL2-associated X protein

NCBI Organism

Homo sapiens

Background Reference 01

Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 - 1324.

Background Reference 02

H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971.

Background Reference 03

Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 - 4312.

Other Product Names

BAXA, Apoptosis regulator BAX, membrane isoform alpha, Bcl2-associated X protein

Tested Applications

IF

Protein ID

388166

Physical Properties

Liquid

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