PEA-15 (phospho Ser104) Antibody

Product Specifications

Background

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

NCBI Gene ID

8682

Swiss Prot

Q15121

Accession Number

NP_003759.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

PEA-15 (phospho Ser104) antibody was raised against a peptide sequence around phosphorylation site of Serine 104 (I-P-S (p) -A-K) derived from Human PEA-15.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

19 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of PEA-15 only when phosphorylated at serine 104.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

PEA15

NCBI Official Name

Phosphoprotein enriched in astrocytes 15

NCBI Organism

Homo sapiens

Background Reference 01

Estelles A., J. Biol. Chem. 271:14800-14806 (1996) .

Background Reference 02

Condorelli G., EMBO J. 17:3858-3866 (1998) .

Background Reference 03

Wolford J.K., Gene 241:143-148 (2000) .

Other Product Names

PE15, PEA15, PED

Tested Applications

WB, IHC

Protein ID

32470612

Physical Properties

Liquid

Curated Selection

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