P90 RSK (phospho Thr573) Antibody

Product Specifications

Background

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.

NCBI Gene ID

6195

Swiss Prot

Q15418

Accession Number

NP_002944.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

P90 RSK (phospho Thr573) antibody was raised against a peptide sequence around phosphorylation site of threonine 573 (L-M-T (p) -P-C) derived from Human p90 RSK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

95 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of P90RSK only when phosphorylated at threonine 573.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

RPS6KA1

NCBI Official Name

Ribosomal protein S6 kinase, 90kDa, polypeptide 1

NCBI Organism

Homo sapiens

Background Reference 01

Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206.

Background Reference 02

Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048.

Background Reference 03

Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835.

Other Product Names

KS6A1, p90RSK1, RSK1, RPS6KA1

Tested Applications

WB, IHC

Protein ID

292457

Physical Properties

Liquid

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