P130 Cas (phospho Tyr410) Antibody

Product Specifications

Background

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

NCBI Gene ID

9564

Swiss Prot

P56945

Accession Number

NP_055382.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

P130 Cas (phospho Tyr410) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 410 (G-V-Y (p) -A-V) derived from Human p130 Cas .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

130 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of p130 Cas only when phosphorylated at tyrosine 410.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

BCAR1

NCBI Official Name

Breast cancer anti-estrogen resistance 1

NCBI Organism

Homo sapiens

Background Reference 01

Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 - 37535.

Background Reference 02

Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 - H2863.

Background Reference 03

Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 - 9189.

Background Reference 04

Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 - 6

Other Product Names

BCAR1, CRKAS, CRK-ASSOCIATED SUBSTRATE

Tested Applications

WB, IHC

Protein ID

44662836

Physical Properties

Liquid

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