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Amyloid beta A4 (phospho Thr743/668) Antibody

Product Specifications

Background

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G (O) and JIP. Inhibits G (o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.

NCBI Gene ID

351

Swiss Prot

P05067

Accession Number

NP_000475.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Amyloid beta A4 (phospho Thr743/668) antibody was raised against a peptide sequence around phosphorylation site of threonine 743 /668 (A-V-T (p) -P-E) derived from Human Amyloid beta A4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-775

Calculated Molecular Weight

140 kDa

Fragment

IgG

Specificity

The antibody detects endogenous levels of Amyloid beta A4 only when phosphorylated at threonine 743/668.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Symbol

APP

NCBI Official Name

Amyloid beta (A4) precursor protein

NCBI Organism

Homo sapiens

Background Reference 01

Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83.

Background Reference 02

Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 - 645

Background Reference 03

Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 – 4338.

Background Reference 04

Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 - 7717

Other Product Names

A4, AD1, APP, APPI, Beta-amyloid protein 42

Tested Applications

WB, IHC, IF

Protein ID

28721

Physical Properties

Liquid

Curated Selection

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