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Twist2 Antibody

Product Specifications

Background

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

NCBI Gene ID

117581

Swiss Prot

Q8WVJ9

Accession Number

NP_476527.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Twist2 antibody was raised against a peptide sequence around aa.26~30 (P-K-R-F-G) derived from Human Twist2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

18 kDa

Specificity

This antibody detects endogenous level of total Twist2 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

TWIST2

NCBI Official Name

Twist family bHLH transcription factor 2

NCBI Organism

Homo sapiens

Background Reference 01

Lee M. S., Lowe G., Flanagan S., Kuchler K., Glackin C. A. Bone 27:591-602 (2000)

Other Product Names

FFDD3, DERMO1, SETLSS, bHLHa39, MGC117334

Tested Applications

WB

Protein ID

17981708

Physical Properties

Liquid

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