CCR5 (CD195) Antibody

Product Specifications

Background

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

NCBI Gene ID

1234

Swiss Prot

P51681

Accession Number

NP_000570.1

Host

Rabbit

Reactivity

Human

Immunogen

CCR5 (CD195) antibody was raised against a peptide sequence around aa.11~15 (D-I-N-Y-Y) derived from Human CCR5 (CD195) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

41 kDa

Specificity

This antibody detects endogenous level of total CCR5 (CD195) protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CCR5

NCBI Official Name

Chemokine (C-C motif) receptor 5 (gene/pseudogene)

NCBI Organism

Homo sapiens

Background Reference 01

Samson M., Labbe O., Mollereau C., Vassart G., Parmentier M. Biochemistry 35:3362-3367 (1996) Raport C. J., Gosling J., Schweichart V. L., Gray P. W., Charo I. F. J. Biol. Chem. 271:17161-17166 (1996) Combadiere C., Ahuja S. K., Tiffany H. L., Murphy P. M. J. Leukoc. Biol. 60:147-152 (1996)