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HDAC3 Antibody

Product Specifications

Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

NCBI Gene ID

8841

Swiss Prot

O15379

Accession Number

NP_003874.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

HDAC3 antibody was raised against a peptide sequence around aa.420~424 (N-D-K-E-S) derived from Human HDAC3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-759

Calculated Molecular Weight

49 kDa

Specificity

This antibody detects endogenous level of total HDAC3 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

HDAC3

NCBI Official Name

Histone deacetylase 3

NCBI Organism

Homo sapiens

Other Product Names

HD3, RPD3, RPD3-2, HD3

Tested Applications

WB

Protein ID

13128862

Physical Properties

Liquid

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