WASP Antibody

Product Specifications

Background

Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.

NCBI Gene ID

7454

Swiss Prot

P42768

Accession Number

NP_000368.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

WASP antibody was raised against a peptide sequence around aa.289~293 (L-I-Y-D-F) derived from Human WASP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

53 kDa

Specificity

This antibody detects endogenous level of total WASP protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

WAS

NCBI Official Name

Wiskott-Aldrich syndrome

NCBI Organism

Homo sapiens

Background Reference 01

Kolluri R., Tolias K. F., Carpenter C. L., Rosen F. S., Kirchhausen T. Proc. Natl. Acad. Sci. U. S. A. 93:5615-5618 (1996) Ramesh N., Anton I. M., Hartwig J. H., Geha R. S. Proc. Natl. Acad. Sci. U. S. A. 94:14671-14676 (1997) Cory G. O. C., Cramer R., Blanchoin L., Ridley A. J. Mol. Cell 11:1229-1239 (2003)