LPAM 1 (Integrin a4, CD49d) Antibody

Product Specifications

Background

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

NCBI Gene ID

3676

Swiss Prot

P13612

Accession Number

NP_000876.3

Host

Rabbit

Reactivity

Human

Immunogen

LPAM-1 (Integrin a4, CD49d) antibody was raised against a peptide sequence around aa.1024~1028 (Y-I-N-S-K) derived from Human LPAM-1 (Integrin α4, CD49d) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

70, 140, 180 kDa

Specificity

This antibody detects endogenous level of total LPAM-1 (Integrin α4, CD49d) protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

ITGA4

NCBI Official Name

Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

NCBI Organism

Homo sapiens

Background Reference 01

Iida J., Meijne A. M. L., Oegema T. R. Jr., Yednock T. A., Kovach N. L., Furcht L. T., McCarthy J. B. J. Biol. Chem. 273:5955-5962 (1998) Liu S., Thomas S. M., Woodside D. G., Rose D. M., Kiosses W. B., Pfaff M., Ginsberg M. H. Nature 402:676-681 (1999)