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ERAB Antibody

Product Specifications

Background

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) .

NCBI Gene ID

3028

Swiss Prot

Q99714

Accession Number

NP_004484.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

ERAB antibody was raised against a peptide sequence around aa.253~257 (L-D-G-A-I) derived from Human ERAB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-705

Calculated Molecular Weight

27 kDa

Specificity

This antibody detects endogenous level of total ERAB protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

HSD17B10

NCBI Official Name

Hydroxysteroid (17-beta) dehydrogenase 10

NCBI Organism

Homo sapiens

Background Reference 01

Holzmann J., Frank P., Loeffler E., Bennett K. L., Gerner C., Rossmanith W. Cell 135:462-474 (2008)

Other Product Names

ABAD, CAMR, ERAB, HCD2, MHBD, HADH2, MRPP2, MRX17, MRX31, SCHAD, MRXS10, SDR5C1, 17b-HSD10, DUPXp11.22, ABAD

Tested Applications

WB

Protein ID

4758504

Physical Properties

Liquid

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