ASH2L Antibody

Product Specifications

Background

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

NCBI Gene ID

9070

Swiss Prot

Q9UBL3

Accession Number

NP_004665.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

ASH2L antibody was raised against a peptide sequence around aa.620~624 (G-R-R-S-P) derived from Human ASH2L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

65, 80 kDa

Specificity

This antibody detects endogenous level of total ASH2L protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

ASH2L

NCBI Official Name

Ash2 (absent, small, or homeotic) -like (Drosophila)

NCBI Organism

Homo sapiens

Background Reference 01

Wysocka J., Myers M. P., Laherty C. D., Eisenman R. N., Herr W. Genes Dev. 17:896-911 (2003) Patel A., Dharmarajan V., Vought V. E., Cosgrove M. S. J. Biol. Chem. 284:24242-24256 (2009)