Fibrillarin Antibody
Product Specifications
Background
Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
NCBI Gene ID
2091
Swiss Prot
P22087
Accession Number
NP_001427.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fibrillarin antibody was raised against a peptide sequence around aa.297~301 (L-T-L-E-P) derived from Human Fibrillarin.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
37 kDa
Specificity
This antibody detects endogenous level of total Fibrillarin protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
FBL
NCBI Official Name
Fibrillarin
NCBI Organism
Homo sapiens
Background Reference 01
Lischwe M. A., Ochs R. L., Reddy R., Cook R. G., Yeoman L. C., Tan E. M., Reichlin M., Busch H. J. Biol. Chem. 260:14304-14310 (1985) Yanagida M., Hayano T., Yamauchi Y., Shinkawa T., Natsume T., Isobe T., Takahashi N. J. Biol. Chem. 279:1607-1614 (2004) Wang Y., Liu J., Zhao H., Lue W., Zhao J., Yang L., Li N., Du X., Ke Y. Biochim. Biophys. Acta 1773:863-868 (2007)
Other Product Names
FIB, FLRN, RNU3IP1, FBL, FIB
Tested Applications
WB
Protein ID
12056465
Physical Properties
Liquid
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