ABCG2 (CD338) Antibody

Product Specifications

Background

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

NCBI Gene ID

9429

Swiss Prot

Q9UNQ0

Accession Number

NP_004818.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

ABCG2 (CD338) antibody was raised against a peptide sequence around aa.160~164 (R-I-N-R-V) derived from Human ABCG2 (CD338) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

65 - 80 kDa

Specificity

This antibody detects endogenous level of total ABCG2 (CD338) protein.

Applications Notes

Western Blot: 1:500

Symbol

ABCG2

NCBI Official Name

ATP-binding cassette, sub-family G (WHITE), member 2

NCBI Organism

Homo sapiens

Background Reference 01

Henriksen U., Gether U., Litman T. J. Cell Sci. 118:1417-1426 (2005) Wakabayashi K., Nakagawa H., Tamura A., Koshiba S., Hoshijima K., Komada M., Ishikawa T. J. Biol. Chem. 282:27841-27846 (2007)