CD56 (NCAM) Antibody
Product Specifications
Background
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains (1) . NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma (2) . CD56 and CD16 are commonly used to identify NK cells although some cells with the T cell markers CD3 and CD4 also express CD56 (3) .
NCBI Gene ID
4684
Swiss Prot
P13591
Accession Number
NP_000606.3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
CD56 (NCAM) antibody was raised against a peptide sequence around aa.850~854 (Q-T-K-E-N) derived from Human CD56 (NCAM) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
120 - 220 kDa
Specificity
This antibody detects endogenous levels of total NCAM protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
NCAM1
NCBI Official Name
Neural cell adhesion molecule 1
NCBI Organism
Homo sapiens
Background Reference 01
Cunningham, B. A. et al. (1987) Science 236, 799-806. Seidenfaden, R. et al. (2003) Mol. Cell. Biol. 23, 5908-5918. Robertson, M. J. and Ritz, J. (1990) Blood 76, 2421-2438.
Other Product Names
CD56, NCAM, MSK39, STK14A, NCAM1
Tested Applications
WB
Protein ID
94420689
Physical Properties
Liquid
Frequently Asked Questions
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