What is the catalog number for MAP2K4 Antibody?

The catalog number for MAP2K4 Antibody is 79-657.

What sizes are available for MAP2K4 Antibody?

MAP2K4 Antibody is available in the following size(s): 0.1 mg.

Is MAP2K4 Antibody in stock?

MAP2K4 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

MAP2K4 Antibody

Product Specifications

Background

SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3) . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4) . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5) .

NCBI Gene ID

6416

Swiss Prot

P45985

Accession Number

NP_003001.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MAP2K4 antibody was raised against a peptide sequence around aa.352~356 (E-S-K-R-P) derived from Human MAP2K4. .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

44 kDa

Specificity

This antibody detects endogenous levels of total MAP2K4 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

MAP2K4

NCBI Official Name

Mitogen-activated protein kinase kinase 4

NCBI Organism

Homo sapiens

Background Reference 01

Davis, R. J. (1994) Trends Biochem. Sci. 19, 470-473. Sanchez, I. et al. (1994) Nature 372, 794-798. Yan, M. et al. (1994) Nature 372, 798-800. Kyriakis, J. M. et al. (1994) Nature 369, 156-160. Park, H. et al. (2002) J. Biol. Chem. 277, 2573-2578.