TFE3 Antibody
Product Specifications
Background
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5') . Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.
NCBI Gene ID
7030
Swiss Prot
P19532
Accession Number
NP_006512.2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
TFE3 antibody was raised against a peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
70 kDa
Specificity
This antibody detects endogenous levels of total TFE3 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
TFE3
NCBI Official Name
Transcription factor binding to IGHM enhancer 3
NCBI Organism
Homo sapiens
Background Reference 01
Clark J., Lu Y. -J., Sidhar S. K., Parker C., Gill S., Oncogene 15:2233-2239 (1997) Weterman M. A. J., Wilbrink M., Proc. Natl. Acad. Sci. U. S. A. 93:15294-15298 (1996)
Other Product Names
TFEA, RCCP2, RCCX1, bHLHe33, MAPTL, MTBT1, TAU, BHLHE33, TFEA
Tested Applications
WB
Protein ID
8659574
Physical Properties
Liquid
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