TRPC6 Antibody

Product Specifications

Background

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .

NCBI Gene ID

7225

Swiss Prot

Q61143

Accession Number

NP_004612.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

TRPC6 antibodypeptide Corresponding to the amino terminal sequence derived from mouse TRPC6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

100 kDa

Specificity

This antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

TRPC6

NCBI Official Name

Transient receptor potential cation channel, subfamily C, member 6

NCBI Organism

Peptide Corresponding to the amino terminal sequence derived from mouse TRPC6.

Background Reference 01

Koichiro Kuwahara et al. (2006) J Clin Invest. 116 (12) : 3114–3126. Mark Estacion et al. (2006) J Physiol. 2006, 572 (Pt 2) : 359–377. Maria A et al. (2006) Proc Natl Acad Sci U S A. 103 (44) : 16586–16591.