Gab1 (Ab 627) Antibody

Product Specifications

Background

The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

2549

Swiss Prot

Q13480

Accession Number

NP_002030.2

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Gab1 (Ab-627) antibody was raised against a peptide sequence around aa.625~629 (V-E-Y-L-D) derived from Human Gab1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

110 kDa

Specificity

This antibody detects endogenous level of total Gab1 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

GAB1

NCBI Official Name

GRB2-associated binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Anders Kallin, et al. (2004) J. Biol. Chem; 279: 17897 - 17904. Hideto Kameda, et al. (2001) Cell Growth Differ; 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol; 158: 773.