Integrin beta3 (Ab 785) Antibody

Product Specifications

Background

The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with Alpha and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct Alpha subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-Alpha2B or the Itg-Beta3 subunit

NCBI Gene ID

3690

Swiss Prot

P05106

Accession Number

NP_000203.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Integrin beta3 (Ab-785) antibody was raised against a peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

110 kDa

Specificity

This antibody detects endogenous level of total Integrin β3 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

ITGB3

NCBI Official Name

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

NCBI Organism

Homo sapiens

Background Reference 01

Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397 (Pt 3) : 437–447Courter DL, et al. (2005) J Biol Chem Apr 01; 280 (13) : 12145-12151Chandhoke SK, et al. (2004) J Cell Sci Mar 15; 117 (Pt 8) : 1431-1441