P38 MAPK (Ab 182) Antibody

Product Specifications

Background

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

NCBI Gene ID

1432

Swiss Prot

Q16539

Accession Number

NP_001306.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

P38 MAPK (Ab-182) antibody was raised against a peptide sequence around aa. 180~184 (T-G-Y-V-A) derived from Human P38 MAPK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

43 kDa

Specificity

This antibody detects endogenous level of total P38MAPK protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

MAPK14

NCBI Official Name

Mitogen-activated protein kinase 14

NCBI Organism

Homo sapiens

Background Reference 01

Ming Zheng, et al. (2005) The FASEB Journal. 19: 109-111Bernt van den et al. (2001) Blink Immunology, 166: 582-587Arshad Rahman, et al. (2004) Am J Physiol Lung Cell Mol Physiol 287: L1017-L1024Osamu Yoshino, et al. (2003) Endocrinology & Metabolism Vol. 88: 2236-2241