IRS 1 (Ab 639) Antibody
Product Specifications
Background
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
NCBI Gene ID
3667
Swiss Prot
P35568
Accession Number
NP_005535.1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
IRS-1 (Ab-639) antibody was raised against a peptide sequence around aa.637~641 (P-K-S-V-S) derived from Human IRS-1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
180 kDa
Specificity
This antibody detects endogenous level of total IRS-1 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Symbol
IRS1
NCBI Official Name
Insulin receptor substrate 1
NCBI Organism
Homo sapiens
Background Reference 01
Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1) : 63-76Kadowaki T, et al. (2000) J Clin Invest; 106 (4) : 459-465Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5) : 2355-2360
Other Product Names
HIRS-1, MAPTL, MTBT1, TAU, IRS-1, IRS1
Tested Applications
WB, IF
Protein ID
5031805
Physical Properties
Liquid
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