PDGF Receptor beta (Ab 751) Antibody

Product Specifications

Background

PDGF Receptor β encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

NCBI Gene ID

5159

Swiss Prot

P09619

Accession Number

NP_002600.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

PDGF Receptor beta (Ab-751) antibody was raised against a peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

190 kDa

Specificity

This antibody detects endogenous level of total PDGF Receptor β protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

PDGFRB

NCBI Official Name

Platelet-derived growth factor receptor, beta polypeptide

NCBI Organism

Homo sapiens

Background Reference 01

Lederle W, et al. (2006) Am J Pathol ; 169 (5) : 1767-1783. Vignais ML, et al. (1999) Mol Cell Biol; 19 (5) : 3727-3735. Herrlich A, et al. (1998) Proc Natl Acad Sci U S A; 95 (15) : 8985-8990. Heuchel R, et al. (1999) Proc Natl Acad Sci U S A; 96 (20) : 11410-11415.