FAK (Ab 397) Antibody

Product Specifications

Background

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.

NCBI Gene ID

5747

Swiss Prot

Q05397

Accession Number

NP_005598.3

Host

Rabbit

Reactivity

Human, Rat

Immunogen

FAK (Ab-397) antibody was raised against a peptide sequence around aa. 395~399 (D-D-Y-A-E) derived from FAK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

125 kDa

Specificity

This antibody detects endogenous levels of total FAK protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

PTK2

NCBI Official Name

Protein tyrosine kinase 2

NCBI Organism

This antibody was raised against a peptide sequence around aa. 395~399 (D-D-Y-A-E) derived from FAK

Background Reference 01

Von Sengbusch A, et al. (2005) Am J Pathol ; 166 (2) : 585-596Fornaro M, et al. (2000) Mol Biol Cell ; 11 (7) : 2235-2249Zhang X, et al. (1999) Proc Natl Acad Sci U S A; 96 (16) : 9021-9026.