GABRB1 (Ab 434) Antibody

Product Specifications

Background

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.

NCBI Gene ID

2560

Swiss Prot

P18505

Accession Number

NP_000803.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

GABRB1 (Ab-434) antibody was raised against a peptide sequence around aa.432~436 (R-A-S-Q-L) derived from Human GABRB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

54 kDa

Specificity

This antibody detects endogenous level of total GABRB1 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

GABRB1

NCBI Official Name

Gamma-aminobutyric acid (GABA) A receptor, beta 1

NCBI Organism

Homo sapiens

Background Reference 01

Collins AL, et al. (2006) Neurogenetics ;7 (3) : 167-174. Ma DQ, et al. (2005) Am J Hum Genet ;77 (3) : 377-388. Edenberg HJ, et al. (2004) Am J Hum Genet ;74 (4) : 705-714.