MSK1 (Ab 376) Antibody

Product Specifications

Background

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1) . Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14) .

NCBI Gene ID

9252

Swiss Prot

O75582

Accession Number

NP_004746.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

MSK1 (Ab-376) antibody was raised against a peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

90 kDa

Specificity

This antibody detects endogenous level of total MSK1 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

RPS6KA5

NCBI Official Name

Ribosomal protein S6 kinase, 90kDa, polypeptide 5

NCBI Organism

Homo sapiens

Background Reference 01

Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68 (2) : 320-344McCOY C, et al. (2005) Biochem J. Apr 15; 387 (Pt 2) : 507-517

Other Product Names

MSK1, RLPK, MSPK1, RPS6KA5

Tested Applications

Protein ID

32528295

Physical Properties

Liquid

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