What is the catalog number for ATM (Ab 1981) Antibody?

The catalog number for ATM (Ab 1981) Antibody is 79-558.

What sizes are available for ATM (Ab 1981) Antibody?

ATM (Ab 1981) Antibody is available in the following size(s): 0.1 mg.

Is ATM (Ab 1981) Antibody in stock?

ATM (Ab 1981) Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

ATM (Ab 1981) Antibody

Product Specifications

Background

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

472

Swiss Prot

Q13315

Accession Number

NP_000042.3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

ATM (Ab-1981) antibody was raised against a peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

350 kDa

Specificity

This antibody detects endogenous level of total ATM protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Symbol

ATM

NCBI Official Name

Ataxia telangiectasia mutated

NCBI Organism

Homo sapiens

Background Reference 01

Gupta A. et al. (2005) Mol Cell Biol. 25 (12) : 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4 (6) : 249-252. Silverman J. et al. (2004) Genes Dev. 18 (17) : 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31 (6) : 1715-1724.