ICAM 1 (Ab 512) Antibody

Product Specifications

Background

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

NCBI Gene ID

3383

Swiss Prot

P05362

Accession Number

NP_000192.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

ICAM-1 (Ab-512) antibody was raised against a peptide sequence around aa. 510~514 (K-K-Y-R-L) derived from Human ICAM-1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

92 kDa

Specificity

This antibody detects endogenous level of total ICAM-1 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

ICAM1

NCBI Official Name

Intercellular adhesion molecule 1

NCBI Organism

Homo sapiens

Background Reference 01

Greenwood J, et al. (2003) J Immunol; 171 (4) : 2099-2108. Zhou Z, et al. (2005) Eur J Pharmacol; 513 (1-2) : 1-8. Chen YH, et al. (2001) J Cell Biochem; 82 (3) : 512-521