BCL XL (Ab 62) Antibody

Product Specifications

Background

Potent inhibitor of cell death. Isoform Bcl-X (L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X (S) isoform promotes apoptosis.

NCBI Gene ID

598

Swiss Prot

Q07817

Accession Number

NP_612815.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

BCL-XL (Ab-62) antibody was raised against a peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

30 kDa

Specificity

This antibody detects endogenous level of total BCL-XL protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

BCL2L1

NCBI Official Name

BCL2-like 1

NCBI Organism

Homo sapiens

Background Reference 01

Basu A, et. al. (2003) Mar 13; 538 (1-3) : 41-7Cheng E. H. -Y. et. al. (1996) Nature 379:554-556. Sattler M. et. al. (1997), Science 275:983-986. Muchmore S. W. et. al (1996) . Nature 381:335-341Yu J., Zhang L. Mol. (2001) Cell 7:673-682