MEK5 (phospho Ser311 / Thr315) Antibody
Product Specifications
Background
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
NCBI Gene ID
29568
Swiss Prot
Q62862
Accession Number
NP_001029159.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MEK5 (phospho-Ser311/ Thr315) antibody was raised against a peptide sequence around phosphorylation site of Serine 311 and threonine 315 (V-N-S (p) I-A-K-T (p) -Y-V) derived from Rat MEK5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
46 kDa
Specificity
This antibody detects endogenous level of MEK5 only when phosphorylated at serine 311 or threonine 315.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
Map2k5
NCBI Official Name
Mitogen activated protein kinase kinase 5
NCBI Organism
Rattus
Background Reference 01
English J. M., Vanderbilt C. A., Xu S., Marcus S., Cobb M. H. J. Biol. Chem. 270:28897-28902 (1995)
Other Product Names
Mek5, CDC2, CDC28A, CDKN1, P34CDC2, Map2k5
Tested Applications
WB
Protein ID
77157802
Physical Properties
Liquid
Curated Selection
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