Sufu (phospho Ser342) Antibody

Product Specifications

Background

SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725) /Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700)

NCBI Gene ID

51684

Swiss Prot

Q9UMX1

Accession Number

NP_057253.2

Host

Rabbit

Reactivity

Human

Immunogen

Sufu (Phospho-Ser342) antibody was raised against a peptide sequence around phosphorylation site of Serine 342 (A-P-S (p) -R-K) derived from Human Sufu.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

54 kDa

Specificity

This antibody detects endogenous level of Sufu protein only when phosphorylated at serine 342.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

SUFU

NCBI Official Name

Suppressor of fused homolog (Drosophila)

NCBI Organism

Homo sapiens

Background Reference 01

Zimmern P, et al. (2010) Neurourol Urodyn. 29 (5) : 715-8. Wang C, et al. (2010) Development. 137 (12) : 2001-9. Rabasseda X. et al. (2010) Drug News Perspect. 23 (4) : 273-5.