Stat2 (phospho Tyr690) Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

6773

Swiss Prot

P52630

Accession Number

NP_005410.1

Host

Rabbit

Reactivity

Human

Immunogen

Stat2 (phospho-Tyr690) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y (p) -L-K) derived from Human Stat2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific , Inflammasomes

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

113 kDa

Specificity

This antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.

Applications Notes

Western Blot: 1:1000

Symbol

STAT2

NCBI Official Name

Signal transducer and activator of transcription 2, 113kDa

NCBI Organism

Homo sapiens

Background Reference 01

Fu X. Y, et al. Proc. Natl. Acad. Sci. U. S. A. 89:7840-7843 (1992) Yan R, et al. Nucleic Acids Res. 23:459-463 (1995) Fu X. Y. Cell 70:323-335 (1992) Sugiyama T, et al. FEBS Lett. 381:191-194 (1996)