A catenin (phospho Ser641) Antibody

Product Specifications

Background

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.

NCBI Gene ID

1495

Swiss Prot

P35221

Accession Number

NP_001894.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A-catenin (Phospho-Ser641) antibody was raised against a peptide sequence around phosphorylation site of serine 641 (D-D-S (p) -D-F) derived from Human α -catenin.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

100 kDa

Specificity

This antibody detects endogenous level of α -catenin only when phosphorylated at serine 641.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

CTNNA1

NCBI Official Name

Catenin (cadherin-associated protein), alpha 1, 102kDa

NCBI Organism

Homo sapiens

Background Reference 01

Hwang, S. G. et al. (2005) J. Biol. Chem. 280, 12758-12765Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.