TrkB (phospho Tyr705) Antibody

Product Specifications

Background

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF) . Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC γ1.

NCBI Gene ID

4915

Swiss Prot

Q16620

Accession Number

NP_001007098.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

TrkB (Phospho-Tyr705) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

140 kDa

Specificity

This antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 705.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

NTRK2

NCBI Official Name

Neurotrophic tyrosine kinase, receptor, type 2

NCBI Organism

Homo sapiens

Background Reference 01

Woronowicz A, et al. Glycobiology. 2007 Jan;17 (1) : 10-24. Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26 (36) : 9250-63. Lewis MA, et al. Mol Pharmacol. 2006 Apr;69 (4) : 1396-404. Cai D, et al. Physiol Genomics. 2006 Feb 14;24 (3) : 191-7.