TrkA (phospho Ser791) Antibody

Product Specifications

Background

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC γ1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC γ1-dependent signaling pathway.

NCBI Gene ID

4914

Swiss Prot

P04629

Accession Number

NP_001007793.1

Host

Rabbit

Reactivity

Human

Immunogen

TrkA (Phospho-Ser791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine791 (P-V-Y (p) -L-D) derived from Human TrkA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

140 kDa

Specificity

This antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.

Applications Notes

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Symbol

NTRK1

NCBI Official Name

Neurotrophic tyrosine kinase, receptor, type 1

NCBI Organism

Homo sapiens

Background Reference 01

Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104 (43) : 17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104 (30) : 12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282 (33) : 24175-84

Other Product Names

MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, MGF, SCF, High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK1 transforming tyrosine kinase protein