Glutamate receptor 2 (Precursor) (phospho Ser880) Antibody

Product Specifications

Background

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

NCBI Gene ID

2891

Swiss Prot

P42262

Accession Number

NP_000817.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Glutamate receptor 2 (Precursor) (phospho-Ser880) antibody was raised against a peptide sequence around phosphorylation site of serine 880 (I-E-S (p) -V-K) derived from Human Glutamate receptor 2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

100 kDa

Specificity

This antibody detects endogenous level of Glutamate receptor 2 (Precursor) only when phosphorylated at serine 880.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

GRIA2

NCBI Official Name

Glutamate receptor, ionotropic, AMPA 2

NCBI Organism

Homo sapiens

Background Reference 01

Cull-Candy, S. et al. (2006) Curr. Opin. Neurobiol. 16, 288-297. Hanley JG, et al. (2002) Neuron. 34 (1) : 53-67

Other Product Names

GLUR2, GLURB, GluA2, HBGR2, GluR-K2, PI12, GRIA2, GluR-2, GluR-B, AMPA 2

Tested Applications

Protein ID

74275354

Physical Properties

Liquid

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